Endocrine Abstracts

Aim: There is emerging evidence that survivors of BMT not only suffer long term endocrine sequelae, but also have an increased risk of cardiovascular disease. The UKCCSG guidelines suggest that BMT survivors should be monitored for cardiac and lung toxicities of previous treatments using cardiac ECHOs and pulmonary function tests (PFTs). We aimed to examine body composition, aerobic fitness, ECHOs and PFTs in adolescent and young adult survivors on GHTx....

Background: There is emerging evidence that BMT survivors not only suffer long term endocrine sequelae, but also have increased risk of cardiovascular disease and T2DM. We examined body composition and cardiovascular and metabolic risk factors in adolescent and young adult survivors.Method: We enrolled 36 BMT survivors (20 male). Seven were pre-pubertal, 9 pubertal, and 20 post-pubertal. We measured body composition by DEXA scan and BMI, and fasted lipid...

The pituitary gland is a dynamic organ that adapts its cellular architecture throughout life, making it an ideal model for the study of stem cells (SCs), their commitment and differentiation. Sox2-expressing cells are bona fide anterior pituitary stem cells (PSCs), which through genetic lineage tracing have been shown to give rise to all anterior pituitary hormone-producing cells both in the embryo and adult. The YAP/TAZ signalling pathway has been previously...